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Weight reduction calcium supplements, magnesium, and you can phosphorus consumption and you can chance of heart attack in the Chinese grownups

Controversial results have been reported about the association of calcium, magnesium, and phosphorus and stroke risk, but none in China. To investigate the association between dietary calcium, magnesium, phosphorus, and stroke incidence in Chinese adults, we collected data from the China Health and Nutrition Survey (CHNS) from 2004 to 2011, including 6411 participants aged 45–79 years and free of stroke at baseline. Diet was assessed by interviews combining 3-d 24-h food recalls and household food inventory weighing at each survey round. The stroke incident was identified based on the validated self-report. Multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). For 32,024 person-years of follow-up, 179 stroke cases were documented. After adjustment for major lifestyle and dietary risk factors, calcium intake was positively associated with reduced stroke risk, and the HR of stroke comparing extreme quartiles was 0.53 (95% CI 0.29–0.96, Ppattern = 0.03). In further stratified analyses, significant heterogeneity across sex strata was found (Pcorrespondence = 0.03). Dietary calcium intake among men was more inversely related to stroke, with HRs being 0.33 (95% CI 0.15–0.76, P trend = 0.02), compared to 1.24 (95% CI 0.46–3.35, Ptrend = 0.89) among women. However, no significant association between stroke and magnesium or phosphorus was revealed. Our findings suggest that higher dietary calcium intake was associated with a lower risk of stroke in Chinese adults, particularly in men.


Once the a good cerebrovascular condition, coronary attack has become the best reason for passing for the setup and you can development countries. An excellent 10% total yearly demise internationally is projected to be attributable in order to they step 1 . Perhaps the stroke survivors, just as much as 15–30% is actually permanently disabled dos , which results in up to 113 billion impairment-adjusted lifestyle ages lost 3 . Asia provides the higher estimated existence chance of coronary arrest around the globe (39.3%) depending on the 2016 in the world load regarding situation (GBD) local study cuatro . Appear to, stroke is a life threatening public health issue to own Asia in the up against the increased ageing populace. Thus, pinpointing brand new modifiable chance items was clicking on the protection and you may the advance from life quality of stroke clients additionally the avoidance out of massive socio-monetary burden.

Weight-loss calcium, magnesium, and you can phosphorus intakes and you can likelihood of coronary arrest inside the Chinese grownups

Whilst the particular etiology is not completely elucidated, stroke tends to be noticed a sickness linked to genetic and you can ecological chance points (specifically dieting) or even the interplay of them facts. Detailed research shows that fat loss variations are advantageous to quit the fresh new onset of coronary arrest 5,six,seven . A close relationship is present ranging from calcium supplements, magnesium, phosphorus, and you will vascular shelter, that are believed essential wellness ramifications getting vascular disorder simply because they normally manage vascular calcification and endothelial breakdown 8,nine . At this point, several studies have checked-out the relationship between these diet consumption and you will stroke exposure 10,11,several , nevertheless the email address details are inconsistent. Instance, search in the Western european society demonstrated magnesium intake, however calcium are significantly linked to a lesser chance of coronary attack 11 . Alternatively, in the us, calcium supplements intake, in place of magnesium, causes ong boys, magnesium consumption is inversely for the coronary attack twelve . In addition, a few of these researches were held into the west populations with a high consumption ones nutrition thirteen,fourteen . not, to the training, absolutely nothing is known regarding association regarding weight-loss calcium supplements, magnesium, and phosphorus consumption having stroke incidence in the Chinese society. The common weight loss intake of those micronutrients certainly one of Chinese some one sipping mainly plant-established diet is actually reported to be less than compared to Europeans and you will Us americans with a lot more whole milk and you may chicken affairs 15 . In this framework, a giant-measure possible data throughout the Chinese society to help you supplement the association’s evidence is undoubtedly necessary. We, for this reason, used analysis from the Asia Health and Nutrients Survey (CHNS) to test the relationship ranging from weight loss calcium supplements, magnesium, and you may phosphorus intakes and you may subsequent frequency regarding heart attack when you look at the Chinese grownups.